A review of the biologic and pharmacologic role of docosapentaenoic acid n-3 [version 2; referees: 2 approved] Previously titled: A review of the biologic and pharmacological role of docosapentaenoic acid
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چکیده
Fish oil contains a complex mixture of omega-3 fatty acids, of which eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) are the three predominant forms. There has been a plethora of previous research on the effects and associations of fish oil supplementation with various clinical manifestations. While the majority of this work was focused on EPA and DHA as the active compounds, emerging research has begun to elucidate the specific role that DPA plays in these physiological processes and its differences with the other omega-3 fatty acids. The purpose of this review is to focus on the new studies undertaken with DPA. This review summarizes the biochemical mechanisms involved in the biosynthesis and metabolism of DPA before focusing on its effects in cardiovascular disease, immune function, and psychiatric and cognitive health. The limited studies point toward a positive role that DPA supplementation can play in these processes and that is separate and distinct from traditional supplementation with DHA and EPA. Puya G Yazdi ( ) Corresponding author: [email protected] Yazdi PG. How to cite this article: A review of the biologic and pharmacologic role of docosapentaenoic acid n-3 [version 2; referees: 2 2014, :256 (doi: ) approved] F1000Research 2 10.12688/f1000research.2-256.v2 © 2014 Yazdi PG. This is an open access article distributed under the terms of the , which Copyright: Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the (CC0 1.0 Public domain dedication). Creative Commons Zero "No rights reserved" data waiver The author(s) declared that no grants were involved in supporting this work. Grant information: Competing interests: PGY is a consultant for Cyvex Nutrition Inc, which is a distributor of nutritional supplements based on DPA and other n-3 fatty acids. 25 Nov 2013, :256 (doi: ) First published: 2 10.12688/f1000research.2-256.v1 1
منابع مشابه
A review of the biologic and pharmacological role of docosapentaenoic acid [version 1; referees: 2 approved with reservations]
Fish oil contains a complex mixture of omega-3 fatty acids, of which eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) are the three predominant forms. There has been a plethora of previous research on the effects and associations of fish oil supplementation with various clinical manifestations. While the majority of this work was previously done on EPA an...
متن کاملA review of the biologic and pharmacologic role of docosapentaenoic acid n-3
Fish oil contains a complex mixture of omega-3 fatty acids, of which eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) are the three predominant forms. There has been a plethora of previous research on the effects and associations of fish oil supplementation with various clinical manifestations. While the majority of this work was focused on EPA and DHA as...
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